pI: 7.12 |
Length (AA): 1011 |
MW (Da): 117662 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 11 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
763 | 1009 | 1pmi () | 158 | 437 | 21.00 | 0 | 0.99 | 0.17 | -0.01 |
19 | 199 | 4uos (A) | 2 | 180 | 16.00 | 0.23 | 0.26 | 0.463331 | -1.43 |
42 | 244 | 2ap3 (A) | 15 | 196 | 29.00 | 0.13 | 0.16 | 0.221591 | -0.02 |
232 | 380 | 1pmi (A) | 64 | 200 | 33.00 | 0.000001 | 0.16 | 0.191179 | 1.85 |
495 | 660 | 4uos (A) | 1 | 177 | 15.00 | 0.1 | 0.14 | 0.313394 | -0.94 |
704 | 1010 | 1pmi (A) | 115 | 438 | 21.00 | 0 | 0.88 | 0.37386 | 0.69 |
774 | 1009 | 1pmi (A) | 204 | 437 | 22.00 | 0 | 0.98 | 0.352732 | 0.94 |
23 | 200 | 4uos (A) | 6 | 183 | 17.00 | 0.37 | 0.37 | 0.470338 | -1.44 |
50 | 266 | 4u0r (A) | 209 | 501 | 19.00 | 0.029 | 0.42 | 0.388951 | -0.59 |
232 | 378 | 1pmi (A) | 64 | 200 | 33.00 | 0.00000057 | 0.12 | 0.167845 | 1.82 |
636 | 1009 | 1pmi (A) | 58 | 441 | 18.00 | 0 | 1 | 0.445897 | 0.41 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, Ring, Sporozoite. | Otto TD Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late trophozoite, Oocyst, Female Gametocyte, Male Gametocyte. | Otto TD PlasmoDB Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | late schizont. | PlasmoDB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | gametocyte. | PlasmoDB |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Ortholog group members (OG5_127555)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G67070 | mannose-6-phosphate isomerase |
Arabidopsis thaliana | AT3G02570 | mannose-6-phosphate isomerase |
Babesia bovis | BBOV_III009640 | phosphomannose isomerase type I family protein |
Brugia malayi | Bm1_52850 | mannose-6-phosphate isomerase, class I family protein |
Brugia malayi | Bm1_32455 | mannose-6-phosphate isomerase, class I family protein |
Candida albicans | CaO19.8968 | mannose-6-phosphate isomerase capable of functionally substituting for S. cerevisiae PMI40 (YER003C) |
Candida albicans | CaO19.1390 | mannose-6-phosphate isomerase capable of functionally substituting for S. cerevisiae PMI40 (YER003C) |
Caenorhabditis elegans | CELE_ZK632.4 | Protein ZK632.4 |
Caenorhabditis elegans | CELE_C05C8.7 | Protein C05C8.7 |
Cryptosporidium hominis | Chro.80224 | hypothetical protein |
Cryptosporidium parvum | cgd8_1920 | mannose-6-phosphate isomerase |
Dictyostelium discoideum | DDB_G0284685 | mannose-6-phosphate isomerase |
Drosophila melanogaster | Dmel_CG8417 | CG8417 gene product from transcript CG8417-RA |
Escherichia coli | b1613 | mannose-6-phosphate isomerase |
Echinococcus granulosus | EgrG_000517700 | mannose 6 phosphate isomerase |
Entamoeba histolytica | EHI_162210 | phosphomannose isomerase, putative |
Echinococcus multilocularis | EmuJ_000517700 | mannose 6 phosphate isomerase |
Homo sapiens | ENSG00000178802 | mannose phosphate isomerase |
Leishmania braziliensis | LbrM.32.1750 | phosphomannose isomerase |
Leishmania donovani | LdBPK_321660.1 | phosphomannose isomerase |
Leishmania infantum | LinJ.32.1660 | phosphomannose isomerase |
Leishmania major | LmjF.32.1580 | phosphomannose isomerase |
Leishmania mexicana | LmxM.31.1580 | phosphomannose isomerase, putative |
Loa Loa (eye worm) | LOAG_01312 | mannose-6-phosphate isomerase |
Loa Loa (eye worm) | LOAG_01345 | mannose-6-phosphate isomerase |
Mycobacterium leprae | ML0765 | probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHO |
Mus musculus | ENSMUSG00000032306 | mannose phosphate isomerase |
Mycobacterium tuberculosis | Rv3255c | Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (pho |
Mycobacterium ulcerans | MUL_2600 | mannose-6-phosphate isomerase ManA |
Neospora caninum | NCLIV_026860 | hypothetical protein |
Oryza sativa | 4325991 | Os01g0127900 |
Oryza sativa | 4346957 | Os09g0389000 |
Plasmodium berghei | PBANKA_1228400 | mannose-6-phosphate isomerase, putative |
Plasmodium falciparum | PF3D7_0801800 | mannose-6-phosphate isomerase, putative |
Plasmodium knowlesi | PKNH_0117100 | mannose-6-phosphate isomerase, putative |
Plasmodium vivax | PVX_093650 | mannose-6-phosphate isomerase, putative |
Plasmodium yoelii | PY03463 | Phosphomannose isomerase type I, putative |
Saccharomyces cerevisiae | YER003C | mannose-6-phosphate isomerase PMI40 |
Schistosoma japonicum | Sjp_0210490 | ko:K01809 mannose-6-phosphate isomerase [EC5.3.1.8], putative |
Schistosoma mansoni | Smp_089590 | mannose-6-phosphate isomerase |
Schmidtea mediterranea | mk4.000517.14 | Mannose-6-phosphate isomerase |
Schmidtea mediterranea | mk4.036709.00 | Mannose-6-phosphate isomerase |
Trypanosoma brucei gambiense | Tbg972.11.16590 | phosphomannose isomerase, putative |
Trypanosoma brucei | Tb927.11.14780 | phosphomannose isomerase |
Trypanosoma congolense | TcIL3000.11.15070 | phosphomannose isomerase, putative |
Trypanosoma cruzi | TcCLB.511717.90 | phosphomannose isomerase, putative |
Trypanosoma cruzi | TcCLB.503677.10 | phosphomannose isomerase, putative |
Toxoplasma gondii | TGME49_260140 | phosphomannose isomerase type I protein |
Theileria parva | TP04_0879 | mannose-6-phosphate isomerase, putative |
Trichomonas vaginalis | TVAG_343390 | mannose-6-phosphate isomerase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.6410 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.6410 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.6410 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.01.6410 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_C05C8.7 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C05C8.7 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_C05C8.7 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_C05C8.7 | Caenorhabditis elegans | slow growth | wormbase |
CELE_C05C8.7 | Caenorhabditis elegans | sterile | wormbase |
YER003C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1228400 | Plasmodium berghei | Slow | plasmo |
TGME49_260140 | Toxoplasma gondii | Probably essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.6
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Candida albicans | mannose-6-phosphate isomerase capable of functionally substituting for S. cerevisiae PMI40 (YER003C) | Compounds | References |
Homo sapiens | mannose phosphate isomerase | Compounds | References |
Saccharomyces cerevisiae | mannose-6-phosphate isomerase PMI40 | Compounds | References |
1 literature reference was collected for this gene.